Open-Source Tools for Trusted Third Parties in Translational Medicine

ACE's minimalistic, icon-like logo: A black shield on white background with a spade in it. In the spade the are the letters ACE.

Advanced Confidentiality Engine



ACE provides a robust solution for pseudonymization services and features high scalability and an integrated audit trail. Its architecture enables the creation of domain hierarchies with inheritable properties that provide both configuration and customization capabilities. Complemented by a modern REST interface and a responsive graphical front-end, ACE is well suited for use by trusted third party personnel as well as integration into data processing pipelines.

Still in development
king logo

Key Index of Names and General Identification Numbers


KING offers advanced identity management features. It is highly scalable and highly configurable. Various record linkage methods are integrated to cover the needs of different use cases. A modern REST interface and responsive graphical front-end ensure efficient and user-friendly usage by trusted third party personnel and allow integration into data processing pipelines.

Still in development
heart logo

Holistic Electronic Agreement Recording Tool


HEART is a specialized tool for the electronic capture and management of consent documents. It is flexibly configurable, supports semantic annotation of consent documents, and is optimized for use on tablets and mobile devices. In addition, HEART provides detailed audit logs so that every consent change can be accurately tracked. The ability to create custom consent templates makes it optimally configurable for a wide range of use cases.

Still in development


Project partners

BIH's Medical Informatics Lab

The Medical Informatics Lab coordinates the project and contributes to the design and implementation of the THS-MED TrustDeck services and their evaluation.

Website of BIH's Medical Informatics Lab
BIH's BeLOVE Office

The BeLOVE Office is leading the independent trusted third party that is still in development, as well as contributing to the design and implementation of THS-MED TrustDeck's services and, in particular, bringing experience from operating trusted third party services to the table.

Website of BIH's BeLOVE Office


Project-relevant publications

  • B Buchner, AC Haber, HK Hahn, F Prasser, H Kusch, U Sax, CO Schmidt. (2021) Das Modell der Datentreuhand in der medizinischen Forschung. Datenschutz und Datensicherheit-DuD 45, 806-810
  • R Bild, M Bialke, ..., F Prasser. (2020) Towards a comprehensive and interoperable representation of consent-based data usage permissions in the German medical informatics initiative. BMC Medical Informatics and Decision Making 20, 1-9
  • F Kohlmayer, R Lautenschläger, F Prasser. (2019) Pseudonymization for research data collection: is the juice worth the squeeze? BMC Medical Informatics and Decision Making 19 (1), 1-7